En salle de conférence C404 à l'IBPS à 11h - Séminaire en anglais

Résumé du séminaire : 

Duringbrain morphogenesis,neuronsare highly motile.However, even thoughmotion is driven by forces, our current understanding of thephysicalinteractions betweenneuronsand their environment is very limited. We here show howlocalmechanicalbrain tissuepropertiescontribute tospecifying andguiding neuronal axons.

In vivotime-lapseatomic force microscopy revealedviscoelasticitygradients in developing brain tissue, which axons followed towards soft. Interfering with brain stiffness and mechanosensitive ion channelsin vivoboth led to aberrant neuronal growth patterns with reduced fasciculation and pathfinding errors. 

Moreover, mechanical signals not only directly impacted neuronal growth but also indirectly by regulating neuronal responses toand the availability ofchemical guidance cues, strongly suggesting that chemical and mechanical signaling pathways are intimately linked, and that their interaction is crucial formorphogenetic events.