Replay our conferences

Seminar - October 10th, 2017

Arc protein: a flexible hub for synaptic plasticity and cognition - Watch the video

Clive BramhamUniversity of Bergen, Bergen, Norway.

Abstract: The adaptive capacity of the brain depends on synaptic plasticity – the ability of a synapse to change in strength in response to use or disuse. Plasticity in neural circuits shapes emotional responses, cognitive flexibility, and underlies memory formation. Aberrant synaptic plasticity impacts human cognition in brain disorders such as autism, schizophrenia, and Alzheimer’s disease. Thus, a major challenge in basic and clinical neuroscience is to elucidate the molecular control of synaptic plasticity. [...]

Seminar - October 6th, 2017

The impact of light and clocks on physiology and behavior - Watch the video

Kristin Tessmar, MPFL, Vienna, Austria.

Abstract: The work in my lab focuses on the impact of light on animal nervous systems, the mechanisms of endogenous clocks and their evolution. These different aspects are partially interconnected as light functions as a zeitgeber for these clocks. The marine bristle worm Platynereis dumerilii harbors a light-entrained circadian, as well as a monthly (circalunar) clock. In order to study the molecular and cellular nature of its circalunar clock, as well as its interaction with the circadian clock, we have established transient and stable transgenesis, inducible specific cell ablations, chemical inibitors, as well as TALEN-mediated genome engineering. [...]

Seminar - June 9th, 2017

Universal genetic code as a key for understanding RNA-protein interactions - Watch the video

Bojan Zagrovic, MPFL & University of Vienna, Austria.

Abstract: The relationship between mRNA and protein sequences as embodied in the universal genetic code is a cornerstone of modern-day molecular biology. In this presentation, I will provide evidence supporting a novel claim that the genetic code can actually be seen as a Rosetta stone for understanding mRNA-protein interactions in general. Conversely, I will defend a claim that RNA-protein interactions could have been an important driving force behind the origin of the genetic code. [...]

Seminar - March 3rd, 2017

Understanding cellular heterogeneity - Watch the video

Sarah TeichmannEMBL-EBI, Cambridge, United Kingdom.

Abstract: From techniques such as microscopy and FACS analysis, we know that many cell populations harbour heterogeneity in morphology and protein expression. With the advent of high throughput single cell RNA-sequencing, we can now quantify transcriptomic cell-to-cell variation. I will discuss technical advances and biological insights into understanding cellular heterogeneity in T cells and ES cells using single cell RNA-sequencing. [...]

Seminar - February 3rd, 2017

Cancer cell of origin and tumor heterogeneity - Watch the video

Cédric BlanpainIRIBHM, Université Libre de Bruxelles, Belgium.

Abstract: For the vast majority of cancers, the cell at the origin of tumor initiation is still unknown. We are using novel genetic approach to identify the cell lineage at the origin of the most frequent epithelial cancers in humans. [...]

Seminar - January 6th, 2017

LUCA, the universal tree of life, and the origin of eukaryotes - Watch the video

Patrick ForterrePasteur Institute, Paris.

Abstract: The nature of LUCA, the topology of the universal tree of life, and the origin of eukaryotes are controversial issues. Recently, several authors have published molecular phylogenetic analyses suggesting that eukaryotes correspond to an archaeal branch (so we are ourselves archaea) and that early branching archaea and bacteria were nano-sized organisms. [...]

Seminar - November 4th, 2016

Axon regeneration in C. elegans: genes, themes and dynamics - Watch the video

Andrew ChisholmUniversity of California at San Diego (UCSD), United States.

Abstract: The ability of axons to regenerate after injury is a fundamental property of animal neurons. Work in a variety of systems has suggested that the molecular mechanisms of axon regeneration may be highly conserved. Genetic studies in C. elegans have highlighted the roles of Calcium dynamics, DLK MAPK signaling cascades, and posts-transcriptional controls at the level of RNA splicing. [...]

Seminar - June 3rd, 2016

Adapting to a stressful start in life - Watch the video

Alex GouldFrancis Crick Institute, London, UK.

Abstract: Animals often encounter stressful environments during development and so have evolved numerous different coping mechanisms. In mammals, it is known that one important strategy for surviving nutrient deprivation is to protect or spare the growth of critical organs such as the CNS at the expense of others. [...]

Seminar - May 20th, 2016

Evaluating genetic adaptation and epigenetic response to pathogen pressures - Watch the video

Lluis Quintana-MurciInstitut Pasteur, Paris.

Abstract: Infectious diseases have been a major cause of human mortality, so natural selection is expected to act strongly on host defence genes. This is particularly expected for innate immunity genes, as they represent the first line of host defence against pathogens. [...]