Genome biology

Our research projects aim at understanding the biology of prokaryotic and eukaryotic genomes. We are combining experimental approaches, based on genetics and genomics, to the quantitative study of genome structure and function based on bioinformatic analysis and modeling. The biology of genomes can only be understood by taking into account both the global mechanisms of genome functioning and their evolutionary history. In particular, we study the relationships between DNA replication, cell size, cell division, cell cycle, mutation rates, adaptation to environmental changes and genome evolution, using both bacteria and yeast as model organisms.


Team themes:

  • Synteny and reconstruction of ancestral genomes
  • Evolution of the spatio-temporal replication profiles of genomes
  • Characterization of the molecular mechanisms involved in the formation of chromosomal rearrangements
  • Characterization of genetic determinants controlling genome stability
  • Study of the natural genetic diversity and variations of nucleotide composition of genomes
  • Patterns and rates of protein sequence evolution
  • Phylogeny of genes, genomes and species


  • IRCAN, Nice France - Gianni Liti
  • Institut Pasteur Paris – Romain Koszul
  • Université de Strasbourg – Joseph Schacherer
  • INRA AgroParisTech, Grigon – Cécile Neuvéglise
  • CNRS Marseille – Bertrand Llorente
  • Isoft, Gif sur Yvette
  • Stowers Institute for Medical Research, Kansas city, USA – Rong Li