Migration and differentiation of hematopoietic stem cells

The production of blood cells is based on multipotent, self-renewing stem cells designated as hematopoietic stem cells (HSCs). The first HSC appear autonomously and in small numbers at the level of the embryonic aorta. They are generated from specialized endothelial cells named hemogenic. HSCs then amplifie in the placenta and fetal liver before reaching in the bone marrow where they will remain lifelong. During these steps, they are in close contact with different cellular microenvironments that play a decisive role in their function.

The mechanism of HSC generation from hemogenic endothelium, the characterization and genetic identity card of HSC populations present simultaneously or sequentially in the embryo and of their microenvironments are the main issues adressed by our team through avian, murine and human models using embryological approaches, functional tests and systems biology methods.


Culture of hemogenic endothelial cells undergoing endothelial to hematopoietic transition (Yvernogeau et al., 2016)