GEMME: A Simple and Fast Global Epistatic Model Predicting Mutational Effects

GEMME is a fast, scalable and simple method to predict mutational landscapes from natural sequences. It demonstrates how deleterious effects of a protein mutation are identified by looking at the closest known sequence accepting the mutation in the evolutionary tree of sequences and at its epistatic changes. The article just appeared in Molecular Biology and Evolution.

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Team Analytical Genomics

Elodie Laine, Yasaman Karami, Alessandra Carbone, GEMME: A Simple and Fast Global Epistatic Model Predicting Mutational Effects, Molecular Biology and Evolution, Volume 36, Issue 11, November 2019, Pages 2604–2619, https://doi.org/10.1093/molbev/msz179