Postdoctoral Position Available - In telomere, DNA damage response and genome stability

Telomeres, the extremities of eukaryotic linear chromosomes, are structurally similar to one side of a double-strand break (DSB). Our lab investigates the cellular responses to telomere shortening or dysfunction and to DSBs, including repair and adaptation to DNA damage. We are interested in the molecular mechanisms of these responses, in their consequences for genome instability, and in how they are similar or different between telomeres and DSBs. The lab uses Saccharomyces cerevisiae as a model organism and combines molecular biology and genetics with microscopy, microfluidics, genomics and mathematical modelling. [...]


Stage M2 - Année universitaire 2021 - 2022 : Développement d'algorithmes d'imagerie pour suivre la dynamique de l'hétérochromatine constitutive.

Profil de formation de l’étudiant : Bioinformatique

Ce projet fait partie d'un programme de recherche plus vaste étudiant l'impact des risques environnementaux sur la robustesse développementale en utilisant comme système modèle les organes sensoriels de Drosophila melanogaster. La robustesse développementale est entendue ici comme l'invariance d'un organe face à un ensemble de perturbations intrinsèques et extrinsèques lors de sa formation. Dans ce contexte, nous proposons d'analyser l'organisation de l'hétérochromatine constitutive lors de la détermination et de l'acquisition de l'identité cellulaire ainsi que lors de la réponse cellulaire aux stress environnementaux. [...]


M2 project proposal (2022): Identifying the neural correlates of an aversive response in zebrafish larvae.

An animal is exposed to many competing external stimuli at any given time. The survival of an animal depends on identifying a single stimulus and executing the appropriate sequence of behavioral responses. One example is the freeze, flight or fight response upon aversive stimuli.  Studies have identified neuronal circuits that mediate these distinct behaviors and theoretical models have been proposed to explain how one circuit is selected amongst different circuits (Mysore and Kothari, 2020). However, the mechanism underlying the selection of only a single neuronal circuit is yet unclear. [...]


M2 internship Project – 2021-2022: Tubule morphogenesis : cellular and molecular aspects of nephric tubule formation in Xenopus

The cellular and molecular mechanisms underlying formation of tubular structures are very diverse within the living. In order to decipher these mechanisms, the laboratory uses as a model the Xenopus pronephros, which is the functional kidney of the tadpole. The Xenopus pronephros consists of a single giant nephron that comprises a filtration unit and a segmented tubular structure where reabsorption takes place. This nephron displays similar functional segmentation and regionalization to that observed in adult mammalian kidneys. [...]


PhD Project 2021-2024 - How the kinase PKA and phosphatases control oocyte meiotic divisions?

Cell division equally partitions the duplicated genome into two daughter cells during the mitotic cell cycle. This process underlies reproduction, development, growth and maintenance of all organisms, while its deregulation produces genome instability and tumorigenesis. Thus, elucidating its basic control is a fundamental question in biology. M-phase entry is driven by changes of protein turn-over and phosphorylations, which ultimately activate the master kinase of cell division, Cdk1 (Cyclin-dependent kinase). This kinase irreversibly triggers entry and progression in mitosis by phosphorylating proteins that underly the mechanics of M-phase. [...]